A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo

par Zhao, Lijie, Han, Xin, Lu, Jianfeng, McEachern, Donna, Wang, Shaomeng
Publié dans Neoplasia (2020)

Reactivation of p53 by MDM2 inhibitor MI-77301 for the treatment of endocrine-resistant breast cancer

par Lu, Jianfeng, McEachern, Donna, Li, Shunqiang, Ellis, Matthew J., Wang, Shaomeng
Publié dans Mol Cancer Ther (2016)

LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling

par Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Lu, Jianfeng, Sun, Haiying, Wang, Shaomeng
Publié 2012

BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

par Bai, Longchuan, Chen, Jianfang, McEachern, Donna, Liu, Liu, Zhou, Haibin, Aguilar, Angelo, Wang, Shaomeng
Publié 2014

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia in Vitro and in Vivo

par Hoffman-Luca, C. Gianna, Ziazadeh, Daniel, McEachern, Donna, Zhao, Yujun, Sun, Wei, Debussche, Laurent, Wang, Shaomeng
Publié dans Clin Cancer Res (2015)

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

par Aguilar, Angelo, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Bernard, Denzil, Deschamps, Jeffrey R., Wang, Shaomeng
Publié dans J Med Chem (2014)

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

par Hoffman-Luca, C. Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng
Publié dans PLoS One (2015)

A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor

par Aguilar, Angelo, Zhou, Haibin, Chen, Jianfang, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer, Stuckey, Jeanne, Wang, Shaomeng
Publié 2013

Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression

par Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng
Publié dans J Med Chem (2018)

Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression

par Chen, Jianfang, Zhou, Haibin, Aguilar, Angelo, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Publié 2012

Structure-based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong in vivo Antitumor Activity

par Zhou, Haibin, Aguilar, Angelo, Chen, Jianfang, Bai, Longchuan, Liu, Liu, Meagher, Jennifer L., Yang, Chao-Yie, McEachern, Donna, Cong, Xin, Stuckey, Jeanne A., Wang, Shaomeng
Publié 2012

Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases

par Yang, Jie, McEachern, Donna, Li, Wenyan, Davis, Mary A., Li, Hua, Morgan, Meredith A., Bai, Longchuan, Sebolt, Jonathan T., Sun, Haiying, Lawrence, Theodore S., Wang, Shaomeng, Sun, Yi
Publié 2011

Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity

par Sun, Haiying, Liu, Liu, Lu, Jianfeng, Bai, Longchuan, Li, Xiaoqin, Nikolovska-Coleska, Zaneta, McEachern, Donna, Yang, Chao-Yie, Qiu, Su, Yi, Han, Sun, Duxin, Wang, Shaomeng
Publié 2011

A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

par Zhao, Yujun, Yu, Shanghai, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Shargary, Sanjeev, Bernard, Denzil, Li, Xiaoqin, Zhao, Ting, Zou, Peng, Sun, Duxin, Wang, Shaomeng
Publié 2013

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong in vivo Antitumor Activity

par Xu, Shilin, Aguilar, Angelo, Huang, Liyue, Xu, Tianfeng, Zheng, Ke, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Zawacki, Kaitlin, Liu, Zhaomin, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng
Publié dans J Med Chem (2020)

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

par Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng
Publié dans Nat Commun (2021)

Potent and Orally Active Small-Molecule Inhibitors of the MDM2-p53 Interaction

par Yu, Shanghai, Qin, Dongguang, Shangary, Sanjeev, Chen, Jianyong, Wang, Guoping, Ding, Ke, McEachern, Donna, Qiu, Su, Nikolovska-Coleska, Zaneta, Miller, Rebecca, Kang, Sanmao, Yang, Dajun, Wang, Shaomeng
Publié 2009

A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete and Durable Tumor Regression in Mice

par Sheng, Rong, Sun, Haiying, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Wang, Guanfeng, Wen, Jianfeng, Min, Ping, Du, Zhenyun, Lu, Huirong, Kang, Sanmao, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Publié 2013

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

par Lu, Jianfeng, Bai, Longchuan, Sun, Haiying, Nikolovska-Coleska, Zaneta, McEachern, Donna, Qiu, Su, Miller, Rebecca S., Yi, Han, Shangary, Sanjeev, Sun, Yi, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Publié 2008

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

par Zhou, Haibin, Bai, Longchuan, Xu, Renqi, McEachern, Donna, Chinnaswamy, Krishnapriya, Li, Ruiting, Wen, Bo, Wang, Mi, Yang, Chao-Yie, Meagher, Jennifer L., Sun, Duxin, Stuckey, Jeanne A., Wang, Shaomeng
Publié dans ACS Med Chem Lett (2021)