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A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor
Our previously reported Bcl-2/Bcl-xL inhibitor, 4, effectively inhibited tumor growth but failed to achieve complete regression in vivo. We have now performed extensive modifications on its pyrrole core structure, which has culminated in the discovery of 32 (BM-1074). Compound 32 binds to Bcl-2 and...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806060/ https://ncbi.nlm.nih.gov/pubmed/23448298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4001105 |
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