SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

[Image: see text] Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. We report herein our extensive in vitro and in vivo evaluations of SD-91, the product of the hydrolysis of our previously reported STAT3 degrader SD-36. SD-91 binds to STAT3 prote...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Zhou, Haibin, Bai, Longchuan, Xu, Renqi, McEachern, Donna, Chinnaswamy, Krishnapriya, Li, Ruiting, Wen, Bo, Wang, Mi, Yang, Chao-Yie, Meagher, Jennifer L., Sun, Duxin, Stuckey, Jeanne A., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201759/
https://ncbi.nlm.nih.gov/pubmed/34141084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00155
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