Structure-based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong in vivo Antitumor Activity

Bcl-2 and Bcl-xL are key apoptosis regulators and attractive cancer therapeutic targets. We have designed and optimized a class of small-molecule inhibitors of Bcl-2 and Bcl-xL containing a 4,5-diphenyl-1H-pyrrole-3-carboxylic acid core structure. A 1.4 Å resolution crystal structure of a lead compo...

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Detalhes bibliográficos
Main Authors: Zhou, Haibin, Aguilar, Angelo, Chen, Jianfang, Bai, Longchuan, Liu, Liu, Meagher, Jennifer L., Yang, Chao-Yie, McEachern, Donna, Cong, Xin, Stuckey, Jeanne A., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417242/
https://ncbi.nlm.nih.gov/pubmed/22747598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300608w
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