A Potent and Selective Small-molecule Degrader of STAT3 Achieves Complete Tumor Regression in vivo

Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic target. We report herein the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over othe...

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Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Bai, Longchuan, Zhou, Haibin, Xu, Renqi, Zhao, Yujun, Chinnaswamy, Krishnapriya, McEachern, Donna, Chen, Jianyong, Yang, Chao-Yie, Liu, Zhaomin, Wang, Mi, Liu, Liu, Jiang, Hui, Wen, Bo, Meagher, Jennifer Lynn, Sun, Duxin, Stuckey, Jeanne, Wang, Shaomeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880868/
https://ncbi.nlm.nih.gov/pubmed/31715132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.10.002
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