Structure-based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Small-molecule inhibitors of Bromodomain and Extra Terminal proteins (BET), including BRD2, BRD3 and BRD4 proteins have therapeutic potential for the treatment of human cancers and other diseases and conditions. In this paper, we report the design, synthesis and evaluation of γ-carboline-containing...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Ran, Xu, Zhao, Yujun, Liu, Liu, Bai, Longchuan, Yang, Chao-Yie, Zhou, Bing, Meagher, Jennifer L., Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474678/
https://ncbi.nlm.nih.gov/pubmed/26080064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00613
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