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Structure-based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Small-molecule inhibitors of Bromodomain and Extra Terminal proteins (BET), including BRD2, BRD3 and BRD4 proteins have therapeutic potential for the treatment of human cancers and other diseases and conditions. In this paper, we report the design, synthesis and evaluation of γ-carboline-containing...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Ran, Xu, Zhao, Yujun, Liu, Liu, Bai, Longchuan, Yang, Chao-Yie, Zhou, Bing, Meagher, Jennifer L., Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Wang, Shaomeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474678/
https://ncbi.nlm.nih.gov/pubmed/26080064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00613
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