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Structure-based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors
Small-molecule inhibitors of Bromodomain and Extra Terminal proteins (BET), including BRD2, BRD3 and BRD4 proteins have therapeutic potential for the treatment of human cancers and other diseases and conditions. In this paper, we report the design, synthesis and evaluation of γ-carboline-containing...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474678/ https://ncbi.nlm.nih.gov/pubmed/26080064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00613 |
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