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Structure-based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

Small-molecule inhibitors of Bromodomain and Extra Terminal proteins (BET), including BRD2, BRD3 and BRD4 proteins have therapeutic potential for the treatment of human cancers and other diseases and conditions. In this paper, we report the design, synthesis and evaluation of γ-carboline-containing...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Ran, Xu, Zhao, Yujun, Liu, Liu, Bai, Longchuan, Yang, Chao-Yie, Zhou, Bing, Meagher, Jennifer L., Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Wang, Shaomeng
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474678/
https://ncbi.nlm.nih.gov/pubmed/26080064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00613
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