A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete and Durable Tumor Regression in Mice

We have designed, synthesized and evaluated a series of new compounds based upon our previously reported bivalent Smac mimetics. This led to the identification of compound 12 (SM-1200), which binds to XIAP, cIAP1 and cIAP2 with K(i) values of 0.5 nM, 3.7 nM and 5.4 nM, respectively, inhibits cell gr...

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Hauptverfasser: Sheng, Rong, Sun, Haiying, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Wang, Guanfeng, Wen, Jianfeng, Min, Ping, Du, Zhenyun, Lu, Huirong, Kang, Sanmao, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806058/
https://ncbi.nlm.nih.gov/pubmed/23651223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400216d
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