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A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete and Durable Tumor Regression in Mice
We have designed, synthesized and evaluated a series of new compounds based upon our previously reported bivalent Smac mimetics. This led to the identification of compound 12 (SM-1200), which binds to XIAP, cIAP1 and cIAP2 with K(i) values of 0.5 nM, 3.7 nM and 5.4 nM, respectively, inhibits cell gr...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806058/ https://ncbi.nlm.nih.gov/pubmed/23651223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400216d |
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