Therapeutic potential and molecular mechanism of a novel, potent, non-peptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment

Smac mimetics are being developed as a new class of anticancer therapies. Since the single-agent activity of Smac mimetics is very limited, rational combinations represent a viable strategy for their clinical development. The combination of Smac mimetics with TRAIL may be particularly attractive due...

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Autori principali: Lu, Jianfeng, McEachern, Donna, Sun, Haiying, Bai, Longchuan, Peng, Yuefeng, Qiu, Su, Miller, Rebecca, Liao, Jinhui, Yi, Han, Liu, Meilan, Bellail, Anita, Hao, Chunhai, Sun, Shi-Yong, Ting, Adrian T., Wang, Shaomeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091962/
https://ncbi.nlm.nih.gov/pubmed/21372226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0864
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