A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

We previously reported the discovery of a class of spirooxindoles as potent and selective small-molecule inhibitors of the MDM2-p53 interaction (MDM2 inhibitors). We report herein our efforts to improve their pharmacokinetic properties and in vivo antitumor activity. Our efforts led to the identific...

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Detalhes bibliográficos
Main Authors: Zhao, Yujun, Yu, Shanghai, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Shargary, Sanjeev, Bernard, Denzil, Li, Xiaoqin, Zhao, Ting, Zou, Peng, Sun, Duxin, Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880646/
https://ncbi.nlm.nih.gov/pubmed/23786219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4005708
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