Quantitative Conformationally Sampled Pharmacophore (CSP) for δ Opioid Ligands: Reevaluation of hydrophobic moieties essential for biological activity

অনুযায়ী Bernard, Denzil, Coop, Andrew, MacKerell, Alexander D.
প্রকাশিত 2007

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment: Miniperspective

অনুযায়ী Zhao, Yujun, Aguilar, Angelo, Bernard, Denzil, Wang, Shaomeng
প্রকাশিত J Med Chem (2014)

Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1–WDR5 Interaction

অনুযায়ী Karatas, Hacer, Townsend, Elizabeth C., Bernard, Denzil, Dou, Yali, Wang, Shaomeng
প্রকাশিত J Med Chem (2010)

Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges

অনুযায়ী Wang, Shaomeng, Zhao, Yujun, Aguilar, Angelo, Bernard, Denzil, Yang, Chao-Yie
প্রকাশিত Cold Spring Harb Perspect Med (2017)

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

অনুযায়ী Chen, Jianyong, Bai, Longchuan, Bernard, Denzil, Nikolovska-Coleska, Zaneta, Gomez, Cindy, Zhang, Jian, Yi, Han, Wang, Shaomeng
প্রকাশিত 2010

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

অনুযায়ী Aguilar, Angelo, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Bernard, Denzil, Deschamps, Jeffrey R., Wang, Shaomeng
প্রকাশিত J Med Chem (2014)

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

অনুযায়ী Karatas, Hacer, Townsend, Elizabeth C., Cao, Fang, Chen, Yong, Bernard, Denzil, Liu, Liu, Lei, Ming, Dou, Yali, Wang, Shaomeng
প্রকাশিত J Am Chem Soc (2012)

Split Renilla Luciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions

অনুযায়ী Jiang, Yiqun, Bernard, Denzil, Yu, Yanke, Xie, Yehua, Zhang, Tao, Li, Yanyan, Burnett, Joseph P., Fu, Xueqi, Wang, Shaomeng, Sun, Duxin
প্রকাশিত 2010

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

অনুযায়ী Chern, Ting-Rong, Liu, Liu, Petrunak, Elyse, Stuckey, Jeanne A., Wang, Mi, Bernard, Denzil, Zhou, Haibin, Lee, Shirley, Dou, Yali, Wang, Shaomeng
প্রকাশিত ACS Med Chem Lett (2020)

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

অনুযায়ী Huang, Chang, Bernard, Denzil, Zhu, Jiaqi, Dash, Radha Charan, Chu, Alexander, Knupp, Alec, Hakey, Anna, Hadden, M. Kyle, Garmendia, Antonio, Tang, Young
প্রকাশিত Virol J (2020)

Follicular lymphoma-associated BTK mutations are inactivating resulting in augmented AKT activation

অনুযায়ী Hu, Nan, Wang, Fangyang, Sun, Tianyu, Xu, Zhengfan, Zhang, Jing, Bernard, Denzil, Xu, Shilin, Wang, Shaomeng, Kaminski, Mark, Devata, Suma, Phillips, Tycel, Malek, Sami N.
প্রকাশিত Clin Cancer Res (2021)

A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

অনুযায়ী Zhao, Yujun, Yu, Shanghai, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Shargary, Sanjeev, Bernard, Denzil, Li, Xiaoqin, Zhao, Ting, Zou, Peng, Sun, Duxin, Wang, Shaomeng
প্রকাশিত 2013

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

অনুযায়ী Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng
প্রকাশিত Nat Commun (2021)

Recurrent mutations in the MTOR regulator RRAGC in follicular lymphoma

অনুযায়ী Ying, Zhang Xiao, Jin, Meiyan, Peterson, Luke F., Bernard, Denzil, Saiya-Cork, Kamlai, Yildiz, Mehmet, Wang, Shaomeng, Kaminski, Mark S., Chang, Alfred E., Klionsky, Daniel J., Malek, Sami N.
প্রকাশিত Clin Cancer Res (2016)

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

অনুযায়ী Zhou, Haibin, Lu, Jianfeng, Liu, Liu, Bernard, Denzil, Yang, Chao-Yie, Fernandez-Salas, Ester, Chinnaswamy, Krishnapriya, Layton, Stephanie, Stuckey, Jeanne, Yu, Qing, Zhou, Weihua, Pan, Zhenqiang, Sun, Yi, Wang, Shaomeng
প্রকাশিত Nat Commun (2017)

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

অনুযায়ী Shangary, Sanjeev, Ding, Ke, Qiu, Su, Nikolovska-Coleska, Zaneta, Bauer, Joshua A., Liu, Meilan, Wang, Guoping, Lu, Yipin, McEachern, Donna, Bernard, Denzil, Bradford, Carol R., Carey, Thomas E., Wang, Shaomeng
প্রকাশিত 2008

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

অনুযায়ী Zhao, Yujun, Liu, Liu, Sun, Wei, Lu, Jianfeng, McEachern, Donna, Xiaoqin, Li, Yu, Shanghai, Bernard, Denzil, Ochsenbein, Philippe, Ferey, Vincent, Carry, Jean-Christophe, Deschamps, Jeffrey R., Sun, Duxin, Wang, Shaomeng
প্রকাশিত 2013

Activating STAT6 mutations in follicular lymphoma

অনুযায়ী Yildiz, Mehmet, Li, Hongxiu, Bernard, Denzil, Amin, Nisar A., Ouillette, Peter, Jones, Siân, Saiya-Cork, Kamlai, Parkin, Brian, Jacobi, Kathryn, Shedden, Kerby, Wang, Shaomeng, Chang, Alfred E., Kaminski, Mark S., Malek, Sami N.
প্রকাশিত Blood (2015)

Follicular lymphoma–associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR

অনুযায়ী Wang, Fangyang, Gatica, Damián, Ying, Zhang Xiao, Peterson, Luke F., Kim, Peter, Bernard, Denzil, Saiya-Cork, Kamlai, Wang, Shaomeng, Kaminski, Mark S., Chang, Alfred E., Phillips, Tycel, Klionsky, Daniel J., Malek, Sami N.
প্রকাশিত J Clin Invest (2019)

Structure-based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction

অনুযায়ী Aguilar, Angelo, Zheng, Ke, Xu, Tianfeng, Xu, Shilin, Huang, Liyue, Fernandez-Salas, Ester, Liu, Liu, Bernard, Denzil, Harvey, Kaitlin P., Foster, Caroline, McEachern, Donna, Stuckey, Jeanne, Chinnaswamy, Krishnapriya, Delproposto, James, Kampf, Jeff W., Wang, Shaomeng
প্রকাশিত J Med Chem (2019)