Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new class of MDM2 small-molecule inhibitors. We...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Yujun, Liu, Liu, Sun, Wei, Lu, Jianfeng, McEachern, Donna, Xiaoqin, Li, Yu, Shanghai, Bernard, Denzil, Ochsenbein, Philippe, Ferey, Vincent, Carry, Jean-Christophe, Deschamps, Jeffrey R., Sun, Duxin, Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806051/
https://ncbi.nlm.nih.gov/pubmed/23641733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3125417
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