Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

[Image: see text] The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or M...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Chern, Ting-Rong, Liu, Liu, Petrunak, Elyse, Stuckey, Jeanne A., Wang, Mi, Bernard, Denzil, Zhou, Haibin, Lee, Shirley, Dou, Yali, Wang, Shaomeng
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294728/
https://ncbi.nlm.nih.gov/pubmed/32551023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00229
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki