Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia

Here we report a comprehensive characterization of our newly developed inhibitor MM-401 that targets the MLL1 H3 lysine (K) 4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activity by blocking MLL1-WDR5 interaction and thus the complex assembly. This novel targeting strateg...

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Main Authors: Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui, Malek, Sami, Wang, Shaomeng, Dou, Yali
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965208/
https://ncbi.nlm.nih.gov/pubmed/24389101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.001
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