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Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia
Here we report a comprehensive characterization of our newly developed inhibitor MM-401 that targets the MLL1 H3 lysine (K) 4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activity by blocking MLL1-WDR5 interaction and thus the complex assembly. This novel targeting strateg...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3965208/ https://ncbi.nlm.nih.gov/pubmed/24389101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.001 |
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