Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia

Here we report a comprehensive characterization of our newly developed inhibitor MM-401 that targets the MLL1 H3 lysine (K) 4 methyltransferase activity. MM-401 is able to specifically inhibit MLL1 activity by blocking MLL1-WDR5 interaction and thus the complex assembly. This novel targeting strateg...

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Detalhes bibliográficos
Main Authors: Cao, Fang, Townsend, Elizabeth C., Karatas, Hacer, Xu, Jing, Li, Li, Lee, Shirley, Liu, Liu, Chen, Yong, Ouillette, Peter, Zhu, Jidong, Hess, Jay L., Atadja, Peter, Lei, Ming, Qin, Zhaohui, Malek, Sami, Wang, Shaomeng, Dou, Yali
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965208/
https://ncbi.nlm.nih.gov/pubmed/24389101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.001
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