MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that desp...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Xu, Jing, Li, Li, Xiong, Jie, denDekker, Aaron, Ye, Andrew, Karatas, Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S, Wang, Shaomeng, Dou, Yali
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869169/
https://ncbi.nlm.nih.gov/pubmed/27462455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.8
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