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MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that desp...
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| Publié dans: | Cell Discov |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869169/ https://ncbi.nlm.nih.gov/pubmed/27462455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.8 |
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