MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that desp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Discov
Prif Awduron: Xu, Jing, Li, Li, Xiong, Jie, denDekker, Aaron, Ye, Andrew, Karatas, Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S, Wang, Shaomeng, Dou, Yali
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869169/
https://ncbi.nlm.nih.gov/pubmed/27462455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.8
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