MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that desp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Discov
Egile Nagusiak: Xu, Jing, Li, Li, Xiong, Jie, denDekker, Aaron, Ye, Andrew, Karatas, Hacer, Liu, Liu, Wang, He, Qin, Zhaohui S, Wang, Shaomeng, Dou, Yali
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869169/
https://ncbi.nlm.nih.gov/pubmed/27462455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.8
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