MLL1 Inhibition Reprograms Epiblast Stem Cells to Naïve Pluripotency

The interconversion between naïve and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can drive reprogramming to naïve pluripotency, or if distinct chromatin states are instead simply a reflection of discrete p...

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Zhang, Hui, Gayen, Srimonta, Xiong, Jie, Zhou, Bo, Shanmugam, Avinash K, Sun, Yuqing, Karatas, Hacer, Liu, Liu, Rao, Rajesh C., Wang, Shaomeng, Nesvizhskii, Alexey I., Kalantry, Sundeep, Dou, Yali
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826731/
https://ncbi.nlm.nih.gov/pubmed/26996599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.02.004
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