PRDM16 suppresses MLL leukemia via intrinsic histone methyltransferase activity

PRDM16 is a transcription cofactor that plays critical roles in development of brown adipose tissue (BAT) as well as maintenance of adult hematopoietic and neural stem cells. Here we report that PRDM16 is a histone H3 K4 methyltransferase on chromatin. Mutation in the N-terminal PR-domain of PRDM16...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Zhou, Bo, Wang, Jingya, Lee, Shirley Y., Xiong, Jie, Bhanu, Natarajan, Guo, Qi, Ma, Peilin, Sun, Yuqing, Rao, Rajesh C., Garcia, Benjamin A., Hess, Jay L., Dou, Yali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061593/
https://ncbi.nlm.nih.gov/pubmed/27151440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.010
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