Structure-based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction

Inhibition of the menin-MLL protein-protein interaction is a promising new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein our structure-based design, synthesis and evaluation of a new class of small-molecule inhibitors of the menin-MLL...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Aguilar, Angelo, Zheng, Ke, Xu, Tianfeng, Xu, Shilin, Huang, Liyue, Fernandez-Salas, Ester, Liu, Liu, Bernard, Denzil, Harvey, Kaitlin P., Foster, Caroline, McEachern, Donna, Stuckey, Jeanne, Chinnaswamy, Krishnapriya, Delproposto, James, Kampf, Jeff W., Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057177/
https://ncbi.nlm.nih.gov/pubmed/31244110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00021
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