Follicular lymphoma–associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR

The discovery of recurrent mutations in subunits of the vacuolar-type H(+)-translocating ATPase (v-ATPase) in follicular lymphoma (FL) highlights a role for the amino acid– and energy-sensing pathway to mTOR in the pathogenesis of this disease. Here, through the use of complementary experimental app...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Fangyang, Gatica, Damián, Ying, Zhang Xiao, Peterson, Luke F., Kim, Peter, Bernard, Denzil, Saiya-Cork, Kamlai, Wang, Shaomeng, Kaminski, Mark S., Chang, Alfred E., Phillips, Tycel, Klionsky, Daniel J., Malek, Sami N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436860/
https://ncbi.nlm.nih.gov/pubmed/30720463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98288
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados