Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

Lignende værker

• Potent and Orally Active Small-Molecule Inhibitors of the MDM2-p53 Interaction
  af: Yu, Shanghai, et al.
  Udgivet: (2009)
• Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
  af: Shangary, Sanjeev, et al.
  Udgivet: (2008)
• Targeting the MDM2-p53 Interaction for Cancer Therapy
  af: Shangary, Sanjeev, et al.
  Udgivet: (2008)
• Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
  af: Shangary, Sanjeev, et al.
  Udgivet: (2009)
• Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins
  af: Long, Jianting, et al.
  Udgivet: (2013)