Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

MDM2 oncoprotein binds directly to the p53 tumor suppressor and inhibits its function in cancers retaining wild-type p53. Blocking this interaction using small molecules is a promising approach to reactivate p53 function and is being pursued as a new anti-cancer strategy. The spiro-oxindole MI-43, a...

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Detalhes bibliográficos
Main Authors: Shangary, Sanjeev, Ding, Ke, Qiu, Su, Nikolovska-Coleska, Zaneta, Bauer, Joshua A., Liu, Meilan, Wang, Guoping, Lu, Yipin, McEachern, Donna, Bernard, Denzil, Bradford, Carol R., Carey, Thomas E., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494594/
https://ncbi.nlm.nih.gov/pubmed/18566224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0140
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