Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

MDM2 oncoprotein binds directly to the p53 tumor suppressor and inhibits its function in cancers retaining wild-type p53. Blocking this interaction using small molecules is a promising approach to reactivate p53 function and is being pursued as a new anti-cancer strategy. The spiro-oxindole MI-43, a...

Full description

Saved in:
Bibliographic Details
Main Authors: Shangary, Sanjeev, Ding, Ke, Qiu, Su, Nikolovska-Coleska, Zaneta, Bauer, Joshua A., Liu, Meilan, Wang, Guoping, Lu, Yipin, McEachern, Donna, Bernard, Denzil, Bradford, Carol R., Carey, Thomas E., Wang, Shaomeng
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494594/
https://ncbi.nlm.nih.gov/pubmed/18566224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0140
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items