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Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors
[Image: see text] We report herein the structure-based design of a class of conformationally constrained, potent, cell-permeable small-molecule inhibitors to target the SH2 domain in STAT3. Compound 11 (CJ-1383) binds to STAT3 with a K(i) value of 0.95 μM, dose-dependently inhibits cellular STAT3 si...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical Society
2010
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892918/ https://ncbi.nlm.nih.gov/pubmed/20596242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100010j |
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