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Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

[Image: see text] We report herein the structure-based design of a class of conformationally constrained, potent, cell-permeable small-molecule inhibitors to target the SH2 domain in STAT3. Compound 11 (CJ-1383) binds to STAT3 with a K(i) value of 0.95 μM, dose-dependently inhibits cellular STAT3 si...

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Autores principales: Chen, Jianyong, Bai, Longchuan, Bernard, Denzil, Nikolovska-Coleska, Zaneta, Gomez, Cindy, Zhang, Jian, Yi, Han, Wang, Shaomeng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2010
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892918/
https://ncbi.nlm.nih.gov/pubmed/20596242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100010j
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