Загрузка...

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

[Image: see text] We report herein the structure-based design of a class of conformationally constrained, potent, cell-permeable small-molecule inhibitors to target the SH2 domain in STAT3. Compound 11 (CJ-1383) binds to STAT3 with a K(i) value of 0.95 μM, dose-dependently inhibits cellular STAT3 si...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Chen, Jianyong, Bai, Longchuan, Bernard, Denzil, Nikolovska-Coleska, Zaneta, Gomez, Cindy, Zhang, Jian, Yi, Han, Wang, Shaomeng
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2010
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892918/
https://ncbi.nlm.nih.gov/pubmed/20596242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100010j
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!