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Quantitative Conformationally Sampled Pharmacophore (CSP) for δ Opioid Ligands: Reevaluation of hydrophobic moieties essential for biological activity

Recent studies have indicated several therapeutic applications for δ opioid agonists and antagonists. To exploit the therapeutic potential of δ opioids developing a structural basis for the activity of ligands at the δ opioid receptor is essential. The conformationally sampled pharmacophore (CSP) me...

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Detalhes bibliográficos
Main Authors: Bernard, Denzil, Coop, Andrew, MacKerell, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631547/
https://ncbi.nlm.nih.gov/pubmed/17367120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0612463
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