A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo

por Zhao, Lijie, Han, Xin, Lu, Jianfeng, McEachern, Donna, Wang, Shaomeng
Publicado en Neoplasia (2020)

Reactivation of p53 by MDM2 inhibitor MI-77301 for the treatment of endocrine-resistant breast cancer

por Lu, Jianfeng, McEachern, Donna, Li, Shunqiang, Ellis, Matthew J., Wang, Shaomeng
Publicado en Mol Cancer Ther (2016)

LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling

por Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Lu, Jianfeng, Sun, Haiying, Wang, Shaomeng
Publicado 2012

BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

por Bai, Longchuan, Chen, Jianfang, McEachern, Donna, Liu, Liu, Zhou, Haibin, Aguilar, Angelo, Wang, Shaomeng
Publicado 2014

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia in Vitro and in Vivo

por Hoffman-Luca, C. Gianna, Ziazadeh, Daniel, McEachern, Donna, Zhao, Yujun, Sun, Wei, Debussche, Laurent, Wang, Shaomeng
Publicado en Clin Cancer Res (2015)

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

por Aguilar, Angelo, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Bernard, Denzil, Deschamps, Jeffrey R., Wang, Shaomeng
Publicado en J Med Chem (2014)

Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment

por Hoffman-Luca, C. Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng
Publicado en PLoS One (2015)

A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor

por Aguilar, Angelo, Zhou, Haibin, Chen, Jianfang, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer, Stuckey, Jeanne, Wang, Shaomeng
Publicado 2013

Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression

por Li, Yangbing, Yang, Jiuling, Aguilar, Angelo, McEachern, Donna, Przybranowski, Sally, Liu, Liu, Yang, Chao-Yie, Wang, Mi, Han, Xin, Wang, Shaomeng
Publicado en J Med Chem (2018)

Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression

por Chen, Jianfang, Zhou, Haibin, Aguilar, Angelo, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Publicado 2012

Structure-based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong in vivo Antitumor Activity

por Zhou, Haibin, Aguilar, Angelo, Chen, Jianfang, Bai, Longchuan, Liu, Liu, Meagher, Jennifer L., Yang, Chao-Yie, McEachern, Donna, Cong, Xin, Stuckey, Jeanne A., Wang, Shaomeng
Publicado 2012

Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases

por Yang, Jie, McEachern, Donna, Li, Wenyan, Davis, Mary A., Li, Hua, Morgan, Meredith A., Bai, Longchuan, Sebolt, Jonathan T., Sun, Haiying, Lawrence, Theodore S., Wang, Shaomeng, Sun, Yi
Publicado 2011

Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity

por Sun, Haiying, Liu, Liu, Lu, Jianfeng, Bai, Longchuan, Li, Xiaoqin, Nikolovska-Coleska, Zaneta, McEachern, Donna, Yang, Chao-Yie, Qiu, Su, Yi, Han, Sun, Duxin, Wang, Shaomeng
Publicado 2011

A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

por Zhao, Yujun, Yu, Shanghai, Sun, Wei, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Shargary, Sanjeev, Bernard, Denzil, Li, Xiaoqin, Zhao, Ting, Zou, Peng, Sun, Duxin, Wang, Shaomeng
Publicado 2013

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong in vivo Antitumor Activity

por Xu, Shilin, Aguilar, Angelo, Huang, Liyue, Xu, Tianfeng, Zheng, Ke, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Zawacki, Kaitlin, Liu, Zhaomin, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng
Publicado en J Med Chem (2020)

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

por Zhou, Haibin, Lu, Jianfeng, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Liu, Liu, McEachern, Donna, Yang, Chao-Yie, Bernard, Denzil, Shen, Hong, Rui, Liangyou, Sun, Yi, Wang, Shaomeng
Publicado en Nat Commun (2021)

Potent and Orally Active Small-Molecule Inhibitors of the MDM2-p53 Interaction

por Yu, Shanghai, Qin, Dongguang, Shangary, Sanjeev, Chen, Jianyong, Wang, Guoping, Ding, Ke, McEachern, Donna, Qiu, Su, Nikolovska-Coleska, Zaneta, Miller, Rebecca, Kang, Sanmao, Yang, Dajun, Wang, Shaomeng
Publicado 2009

A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete and Durable Tumor Regression in Mice

por Sheng, Rong, Sun, Haiying, Liu, Liu, Lu, Jianfeng, McEachern, Donna, Wang, Guanfeng, Wen, Jianfeng, Min, Ping, Du, Zhenyun, Lu, Huirong, Kang, Sanmao, Guo, Ming, Yang, Dajun, Wang, Shaomeng
Publicado 2013

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

por Lu, Jianfeng, Bai, Longchuan, Sun, Haiying, Nikolovska-Coleska, Zaneta, McEachern, Donna, Qiu, Su, Miller, Rebecca S., Yi, Han, Shangary, Sanjeev, Sun, Yi, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Publicado 2008

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

por Zhou, Haibin, Bai, Longchuan, Xu, Renqi, McEachern, Donna, Chinnaswamy, Krishnapriya, Li, Ruiting, Wen, Bo, Wang, Mi, Yang, Chao-Yie, Meagher, Jennifer L., Sun, Duxin, Stuckey, Jeanne A., Wang, Shaomeng
Publicado en ACS Med Chem Lett (2021)