SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

Por Li, Ying, Xu, Wei, McBurney, Michael W., Longo, Valter D.
Publicado em 2008

Sirtuin 1 Is a Negative Regulator of Parathyroid Hormone Stimulation of Matrix Metalloproteinase 13 Expression in Osteoblastic Cells: ROLE OF SIRTUIN 1 IN THE ACTION OF PTH ON OSTE...

Por Fei, Yurong, Shimizu, Emi, McBurney, Michael W., Partridge, Nicola C.
Publicado no J Biol Chem (2015)

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription

Por Ghosh, Hiyaa S., Spencer, James V., Ng, Bobby, McBurney, Michael W., Robbins, Paul D.
Publicado em 2007

SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons

Por Panossian, Lori, Fenik, Polina, Zhu, Yan, Zhan, Guanxia, McBurney, Michael W., Veasey, Sigrid
Publicado em 2011

SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress

Por McBurney, Michael W., Clark-Knowles, Katherine V., Caron, Annabelle Z., Gray, Douglas A.
Publicado em 2013

SIRT1 Catalytic Activity Has Little Effect on Tumor Formation and Metastases in a Mouse Model of Breast Cancer

Por Clark-Knowles, Katherine V., Dewar-Darch, Danielle, Jardine, Karen E., McBurney, Michael W.
Publicado em 2013

Modulation of Tumorigenesis by Dietary Intervention Is Not Mediated by SIRT1 Catalytic Activity

Por Clark-Knowles, Katherine V., Dewar-Darch, Danielle, Jardine, Karen E., McBurney, Michael W.
Publicado no PLoS One (2014)

Sirt1-deficiency causes defective protein quality control

Por Tomita, Takuya, Hamazaki, Jun, Hirayama, Shoshiro, McBurney, Michael W., Yashiroda, Hideki, Murata, Shigeo
Publicado no Sci Rep (2015)

A local mechanism mediates NAD-dependent protection of axon degeneration

Por Wang, Jing, Zhai, Qiwei, Chen, Ying, Lin, Estelle, Gu, Wei, McBurney, Michael W., He, Zhigang
Publicado em 2005

SIRT1-mediated acute cardioprotection

Por Nadtochiy, Sergiy M., Yao, Hongwei, McBurney, Michael W., Gu, Wei, Guarente, Leonard, Rahman, Irfan, Brookes, Paul S.
Publicado em 2011

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

Por Fulco, Marcella, Cen, Yana, Zhao, Po, Hoffman, Eric P., McBurney, Michael W., Sauve, Anthony A., Sartorelli, Vittorio
Publicado em 2008

Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: Implication in pathogenesis of COPD

Por Hwang, Jae-woong, Chung, Sangwoon, Sundar, Isaac K., Yao, Hongwei, Arunachalam, Gnanapragasam, McBurney, Michael W., Rahman, Irfan
Publicado em 2010

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

Por McBurney, Michael W., Yang, Xiaofeng, Jardine, Karen, Hixon, Mary, Boekelheide, Kim, Webb, John R., Lansdorp, Peter M., Lemieux, Madeleine
Publicado em 2003

Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis

Por Wu, Jingxia, Zhang, Fang, Yan, Menghong, Wu, Dongmei, Yu, Qiujing, Zhang, Yi, Zhou, Ben, McBurney, Michael W., Zhai, Qiwei
Publicado em 2011

Sirtuin 1 Enzymatic Activity Is Required for Cartilage Homeostasis In Vivo in a Mouse Model

Por Gabay, Odile, Sanchez, Christelle, Dvir-Ginzberg, Mona, Gagarina, Viktoria, Zaal, Kristien J., Song, Yingjie, He, Xiao Hong, McBurney, Michael W.
Publicado em 2013

Sirt1-deficient mice exhibit an altered cartilage phenotype

Por Gabay, Odile, Zaal, Kristien J., Sanchez, Christelle, Dvir-Ginzberg, Mona, Gagarina, Viktoria, Song, Yingjie, He, Xiao Hong, McBurney, Michael W.
Publicado no Joint Bone Spine (2013)

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

Por Mercken, Evi M, Hu, Jia, Krzysik-Walker, Susan, Wei, Min, Li, Ying, McBurney, Michael W, de Cabo, Rafael, Longo, Valter D
Publicado em 2014

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Por Picard, Frédéric, Kurtev, Martin, Chung, Namjin, Topark-Ngarm, Acharawan, Senawong, Thanaset, de Oliveira, Rita Machado, Leid, Mark, McBurney, Michael W., Guarente, Leonard
Publicado em 2004

Reversible modulation of SIRT1 activity in a mouse strain

Por Clark-Knowles, Katherine V., He, Xiaohong, Jardine, Karen, Coulombe, Josée, Dewar-Darch, Danielle, Caron, Annabelle Z., Gray, Douglas A., McBurney, Michael W.
Publicado no PLoS One (2017)

AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

Por Um, Jee-Hyun, Park, Sung-Jun, Kang, Hyeog, Yang, Shutong, Foretz, Marc, McBurney, Michael W., Kim, Myung K., Viollet, Benoit, Chung, Jay H.
Publicado em 2010