Sirt1-deficient mice exhibit an altered cartilage phenotype

OBJECTIVE: We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro. Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout (KO) mice. METHOD: Articular cartilage was harvested from hind paws of 1-week and 3-week-old mice carrying wild type (...

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Bibliographic Details
Published in:Joint Bone Spine
Main Authors: Gabay, Odile, Zaal, Kristien J., Sanchez, Christelle, Dvir-Ginzberg, Mona, Gagarina, Viktoria, Song, Yingjie, He, Xiao Hong, McBurney, Michael W.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288855/
https://ncbi.nlm.nih.gov/pubmed/23587642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbspin.2013.01.001
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