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Sirt1-deficient mice exhibit an altered cartilage phenotype
OBJECTIVE: We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro. Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout (KO) mice. METHOD: Articular cartilage was harvested from hind paws of 1-week and 3-week-old mice carrying wild type (...
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| Publicado no: | Joint Bone Spine |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4288855/ https://ncbi.nlm.nih.gov/pubmed/23587642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbspin.2013.01.001 |
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