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SirT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway

OBJECTIVE: The protein deacetylase SirT1 inhibits apoptosis in a variety of cell systems by distinct mechanisms, yet its role in chondrocyte death has not been explored. Here we assess the role of SirT1 in the survival of osteoarthritic human chondrocytes. METHODS: SirT1, PTP1B, PTP1Bmutant expressi...

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Détails bibliographiques
Auteurs principaux: Gagarina, Viktoria, Gabay, Odile, Dvir-Ginzberg, Mona, Lee, Eun-Jin, Brady, Jillian K., Quon, Michael J., Hall, David J.
Format: Artigo
Langue:Inglês
Publié: 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923474/
https://ncbi.nlm.nih.gov/pubmed/20131294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27369
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