75kDa SirT1 Blocks TNFα-Mediated Apoptosis in Human Osteoarthritic Chondrocytes

OBJECTIVE: SirT1 has been previously implicated in the regulation of human cartilage homeostasis and chondrocyte survival. Exposing human osteoarthritic chondrocytes to TNFα generates a stable and enzymatically inactive 75kDa form of SirT1 (75SirT1) via Cathepsin B-mediated cleavage. Because 75SirT1...

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Main Authors: Oppenheimer, Hanna, Gabay, Odile, Meir, Hadar, Haze, Amir, Kandel, Leonid, Liebergall, Meir, Gagarina, Viktoria, Lee, Eun Jin, Dvir-Ginzberg, Mona
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269551/
https://ncbi.nlm.nih.gov/pubmed/21987377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33407
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