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Tumor Necrosis Factor α–Mediated Cleavage and Inactivation of SirT1 in Human Osteoarthritic Chondrocytes
OBJECTIVE: The protein deacetylase SirT1 positively regulates cartilage-specific gene expression, while the proinflammatory cytokine tumor necrosis factor α (TNFα) negatively regulates these same genes. This study was undertaken to test the hypothesis that SirT1 is adversely affected by TNFα, result...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174010/ https://ncbi.nlm.nih.gov/pubmed/21305533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30279 |
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