The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

The yeast Sir2p protein has an essential role in maintaining telomeric and mating type genes in their transcriptionally inactive state. Mammalian cells have a very large proportion of their genome inactive and also contain seven genes that have regions of homology with the yeast sir2 gene. One of th...

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Detalhes bibliográficos
Main Authors: McBurney, Michael W., Yang, Xiaofeng, Jardine, Karen, Hixon, Mary, Boekelheide, Kim, Webb, John R., Lansdorp, Peter M., Lemieux, Madeleine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140671/
https://ncbi.nlm.nih.gov/pubmed/12482959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.38-54.2003
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