SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

The SIRT1 deacetylase is one of the best-studied putative mediators of some of the anti-aging effects of calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan...

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Autores principales: Mercken, Evi M, Hu, Jia, Krzysik-Walker, Susan, Wei, Min, Li, Ying, McBurney, Michael W, de Cabo, Rafael, Longo, Valter D
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Short Takes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907112/
https://ncbi.nlm.nih.gov/pubmed/23941528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12151
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