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SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
The SIRT1 deacetylase is one of the best-studied putative mediators of some of the anti-aging effects of calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespan...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3907112/ https://ncbi.nlm.nih.gov/pubmed/23941528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12151 |
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