Sirtuin Chemical Mechanisms

por Sauve, Anthony A.
Publicado em 2010

NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity

por Yang, Tianle, Sauve, Anthony A.
Publicado em 2006

Diastereocontrolled Electrophilic Fluorinations of 2-Deoxyribonolactone: Syntheses of All Corresponding 2-Deoxy-2-fluoro-lactones and 2’-Deoxy-2’-fluoro-NAD(+)s

por Cen, Yana, Sauve, Anthony A.
Publicado em 2009

Transition state of ADP-ribosylation of acetyllysine catalyzed by Archeaglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches

por Cen, Yana, Sauve, Anthony A.
Publicado em 2010

NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy

por Yang, Yue, Sauve, Anthony A.
Publicado no Biochim Biophys Acta (2016)

Synthesis of β-nicotinamide riboside using an efficient two-step methodology

por Zhang, Ning, Sauve, Anthony A.
Publicado no Curr Protoc Nucleic Acid Chem (2017)

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

por Cantó, Carles, Sauve, Anthony A., Bai, Peter
Publicado em 2013

NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase

por Yang, Yue, Zhang, Ning, Zhang, Guoan, Sauve, Anthony A.
Publicado no Nat Metab (2020)

Dihydronicotinamide riboside is a potent NAD(+) concentration enhancer in vitro and in vivo

por Yang, Yue, Mohammed, Farheen Sultana, Zhang, Ning, Sauve, Anthony A.
Publicado no J Biol Chem (2019)

High Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into Catalytic Mechanism and Inhibition by Aldehydes,

por French, Jarrod B., Cen, Yana, Sauve, Anthony A., Ealick, Steven E.
Publicado em 2010

Mechanism-based affinity capture of sirtuins

por Cen, Yana, Falco, Jessica N., Xu, Ping, Youn, Dou Yeon, Sauve, Anthony A.
Publicado em 2010

Lethal cardiomyopathy in mice lacking transferrin receptor in the heart

por Xu, Wenjing, Barrientos, Tomasa, Mao, Lan, Rockman, Howard A., Sauve, Anthony A., Andrews, Nancy C.
Publicado no Cell Rep (2015)

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

por Fulco, Marcella, Cen, Yana, Zhao, Po, Hoffman, Eric P., McBurney, Michael W., Sauve, Anthony A., Sartorelli, Vittorio
Publicado em 2008

Identification of the Aryl Hydrocarbon Receptor Target Gene TiPARP as a Mediator of Suppression of Hepatic Gluconeogenesis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and of Nicotinamid...

por Diani-Moore, Silvia, Ram, Payal, Li, Xintian, Mondal, Prosenjit, Youn, Dou Yeon, Sauve, Anthony A., Rifkind, Arleen B.
Publicado em 2010

Characterization of Nicotinamidases: Steady-State Kinetic Parameters, Class-wide Inhibition by Nicotinaldehydes and Catalytic Mechanism

por French, Jarrod B., Cen, Yana, Vrablik, Tracy L., Xu, Ping, Allen, Eleanor, Hanna-Rose, Wendy, Sauve, Anthony A.
Publicado em 2010

Dual Mode Action of Mangiferin in Mouse Liver under High Fat Diet

por Lim, Jihyeon, Liu, Zhongbo, Apontes, Pasha, Feng, Daorong, Pessin, Jeffrey E., Sauve, Anthony A., Angeletti, Ruth H., Chi, Yuling
Publicado em 2014

Global Analysis of Transcriptional Regulation by Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase in MCF-7 Human Breast Cancer Cells

por Frizzell, Kristine M., Gamble, Matthew J., Berrocal, Jhoanna G., Zhang, Tong, Krishnakumar, Raga, Cen, Yana, Sauve, Anthony A., Kraus, W. Lee
Publicado em 2009

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expr...

por Gong, Bing, Pan, Yong, Vempati, Prashant, Zhao, Wei, Knable, Lindsay, Ho, Lap, Wang, Jun, Sastre, Magdalena, Ono, Kenjiro, Sauve, Anthony A., Pasinetti, Giulio M.
Publicado em 2013

Enzymes in the NAD(+) Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

por Zhang, Tong, Berrocal, Jhoanna G., Frizzell, Kristine M., Gamble, Matthew J., DuMond, Michelle E., Krishnakumar, Raga, Yang, Tianle, Sauve, Anthony A., Kraus, W. Lee
Publicado em 2009

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

por Cerutti, Raffaele, Pirinen, Eija, Lamperti, Costanza, Marchet, Silvia, Sauve, Anthony A., Li, Wei, Leoni, Valerio, Schon, Eric A., Dantzer, Françoise, Auwerx, Johan, Viscomi, Carlo, Zeviani, Massimo
Publicado em 2014