Enzymes in the NAD(+) Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

In mammals, nic o tin a mide phosphoribosyltransferase (NAMPT) and nic o tin a mide mononucleotide ad en y lyltransferase 1 (NMNAT-1) constitute a nuclear NAD(+) salvage pathway which regulates the functions of NAD(+)-de pend ent enzymes such as the protein deacetylase SIRT1. One of the major functi...

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Detalhes bibliográficos
Main Authors: Zhang, Tong, Berrocal, Jhoanna G., Frizzell, Kristine M., Gamble, Matthew J., DuMond, Michelle E., Krishnakumar, Raga, Yang, Tianle, Sauve, Anthony A., Kraus, W. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740465/
https://ncbi.nlm.nih.gov/pubmed/19478080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016469
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