Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD(+) Synthase

NMNAT-1 and PARP-1, two key enzymes in the NAD(+) metabolic pathway, localize to the nucleus where integration of their enzymatic activities has the potential to control a variety of nuclear processes. Using a variety of biochemical, molecular, cell-based, and genomic assays, we show that NMNAT-1 an...

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Autors principals: Zhang, Tong, Berrocal, Jhoanna G., Yao, Jie, DuMond, Michelle E., Krishnakumar, Raga, Ruhl, Donald D., Ryu, Keun Woo, Gamble, Matthew J., Kraus, W. Lee
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320990/
https://ncbi.nlm.nih.gov/pubmed/22334709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304469
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