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CIRCADIAN CONTROL OF THE NAD(+) SALVAGE PATHWAY BY CLOCK-SIRT1
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is counterbalanced by the NAD(+)-dependent histone deacetylase SIRT1. Here we show that intracellular NAD(+) levels cycle w...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6501775/ https://ncbi.nlm.nih.gov/pubmed/19286518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170803 |
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