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CIRCADIAN CONTROL OF THE NAD(+) SALVAGE PATHWAY BY CLOCK-SIRT1
Many metabolic and physiological processes display circadian oscillations. We have shown that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is counterbalanced by the NAD(+)-dependent histone deacetylase SIRT1. Here we show that intracellular NAD(+) levels cycle w...
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| Vydáno v: | Science |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6501775/ https://ncbi.nlm.nih.gov/pubmed/19286518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170803 |
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