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Lethal cardiomyopathy in mice lacking transferrin receptor in the heart

Both iron overload and iron deficiency have been associated with cardiomyopathy and heart failure, but cardiac iron utilization is incompletely understood. We hypothesized that transferrin receptor (Tfr1) might play a role in cardiac iron uptake and used gene targeting to examine the role of Tfr1 in...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Xu, Wenjing, Barrientos, Tomasa, Mao, Lan, Rockman, Howard A., Sauve, Anthony A., Andrews, Nancy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618069/
https://ncbi.nlm.nih.gov/pubmed/26456827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.023
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