Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Calorie restriction extends lifespan in organisms ranging from yeast to mammals1. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction2. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals;...

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Detalhes bibliográficos
Main Authors: Picard, Frédéric, Kurtev, Martin, Chung, Namjin, Topark-Ngarm, Acharawan, Senawong, Thanaset, de Oliveira, Rita Machado, Leid, Mark, McBurney, Michael W., Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820247/
https://ncbi.nlm.nih.gov/pubmed/15175761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02583
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