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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Calorie restriction extends lifespan in organisms ranging from yeast to mammals1. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction2. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals;...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820247/ https://ncbi.nlm.nih.gov/pubmed/15175761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02583 |
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