Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secret...

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Detalhes bibliográficos
Main Authors: Bordone, Laura, Motta, Maria Carla, Picard, Frederic, Robinson, Ashley, Jhala, Ulupi S, Apfeld, Javier, McDonagh, Thomas, Lemieux, Madeleine, McBurney, Michael, Szilvasi, Akos, Easlon, Erin J, Lin, Su-Ju, Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1318478/
https://ncbi.nlm.nih.gov/pubmed/16366736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040031
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