CONVERTING HUMAN PLURIPOTENT STEM CELLS INTO BETA CELLS: RECENT ADVANCES AND FUTURE CHALLENGES

Por Mayhew, Christopher N., Wells, James M.
Publicado em 2010

Repression of Ah Receptor and Induction of Transforming Growth Factor-β Genes in DEN-Induced Mouse Liver Tumors

Por Peng, Li, Mayhew, Christopher N., Schnekenburger, Michael, Knudsen, Erik S., Puga, Alvaro
Publicado em 2008

Unique Impact of RB Loss on Hepatic Proliferation: TUMORIGENIC STRESSES UNCOVER DISTINCT PATHWAYS OF CELL CYCLE CONTROL

Por Reed, Christopher A., Mayhew, Christopher N., McClendon, A. Kathleen, Knudsen, Erik S.
Publicado em 2010

RB Tumor Suppressive Function in Response to Xenobiotic Hepatocarcinogens

Por Reed, Christopher, Hutcheson, Jack, Mayhew, Christopher N., Witkiewicz, Agnieszka K., Knudsen, Erik S.
Publicado em 2014

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Por Ulm, Ashley, Mayhew, Christopher N., Debley, Jason, Khurana Hershey, Gurjit K., Ji, Hong
Publicado no J Vis Exp (2016)

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

Por Bosco, Emily E., Mayhew, Christopher N., Hennigan, Robert F., Sage, Julien, Jacks, Tyler, Knudsen, Erik S.
Publicado em 2004

Proliferative suppression by CDK4/6 inhibition: complex function of the RB-pathway in liver tissue and hepatoma cells

Por Rivadeneira, Dayana B, Mayhew, Christopher N, Thangavel, Chellappagounder, Sotillo, Elena, Reed, Christopher A, Graña, Xavier, Knudsen, Erik S
Publicado em 2010

HSF1-Tpr Interaction Facilitates Export of Stress-Induced hsp70 mRNA

Por Skaggs, Hollie S., Xing, Hongyan, Wilkerson, Donald C., Murphy, Lynea A., Hong, Yiling, Mayhew, Christopher N., Sarge, Kevin D.
Publicado em 2007

Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells

Por Ji, Hong, Zhang, Xue, Oh, Sunghee, Mayhew, Christopher N., Ulm, Ashley, Somineni, Hari K., Ericksen, Mark, Wells, James M., Khurana Hershey, Gurjit K.
Publicado no J Allergy Clin Immunol (2014)

RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms

Por Angus, Steven P., Mayhew, Christopher N., Solomon, David A., Braden, Wesley A., Markey, Michael P., Okuno, Yukiko, Cardoso, M. Cristina, Gilbert, David M., Knudsen, Erik S.
Publicado em 2004

High-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Plurip...

Por Chlon, Timothy M., Hoskins, Elizabeth E., Mayhew, Christopher N., Wikenheiser-Brokamp, Kathryn A., Davies, Stella M., Mehta, Parinda, Myers, Kasiani C., Wells, James M., Wells, Susanne I.
Publicado em 2014

Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology

Por Sun, Ying, Florer, Jane, Mayhew, Christopher N., Jia, Zhanfeng, Zhao, Zhiying, Xu, Kui, Ran, Huimin, Liou, Benjamin, Zhang, Wujuan, Setchell, Kenneth D. R., Gu, Jianguo, Grabowski, Gregory A.
Publicado no PLoS One (2015)

Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage

Por Chlon, Timothy M., Ruiz-Torres, Sonya, Maag, Logan, Mayhew, Christopher N., Wikenheiser-Brokamp, Kathryn A., Davies, Stella M., Mehta, Parinda, Myers, Kasiani C., Wells, James M., Wells, Susanne I.
Publicado no Stem Cell Reports (2016)

Modeling human development and disease in pluripotent stem cell-derived gastric organoids

Por McCracken, Kyle W., Catá, Emily M., Crawford, Calyn M., Sinagoga, Katie L., Schumacher, Michael, Rockich, Briana E., Tsai, Yu-Hwai, Mayhew, Christopher N., Spence, Jason R., Zavros, Yana, Wells, James M.
Publicado no Nature (2014)

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Por Spence, Jason R., Mayhew, Christopher N., Rankin, Scott A., Kuhar, Matthew, Vallance, Jefferson E., Tolle, Kathryn, Hoskins, Elizabeth E., Kalinichenko, Vladimir V., Wells, Susanne I., Zorn, Aaron M., Shroyer, Noah F., Wells, James M.
Publicado em 2010

Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration

Por Gilbert, Shila, Nivarthi, Harini, Mayhew, Christopher N., Lo, Yuan-Hung, Noah, Taeko K., Vallance, Jefferson, Rülicke, Thomas, Müller, Mathias, Jegga, Anil G., Tang, Wenjuan, Zhang, Dongsheng, Helmrath, Michael, Shroyer, Noah, Moriggl, Richard, Han, Xiaonan
Publicado no Stem Cell Reports (2015)

RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage

Por McClendon, A. Kathleen, Dean, Jeffry L., Ertel, Adam, Fu, Zhiyan, Rivadeneira, Dayana B., Reed, Christopher A., Bourgo, Ryan J., Witkiewicz, Agnieszka, Addya, Sankar, Mayhew, Christopher N., Grimes, H. Leighton, Fortina, Paolo, Knudsen, Erik S.
Publicado no Gastroenterology (2011)

In vitro generation of human pluripotent stem cell derived lung organoids

Por Dye, Briana R, Hill, David R, Ferguson, Michael AH, Tsai, Yu-Hwai, Nagy, Melinda S, Dyal, Rachel, Wells, James M, Mayhew, Christopher N, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
Publicado no eLife (2015)

An in vivo model of human small intestine using pluripotent stem cells

Por Watson, Carey L, Mahe, Maxime M, Múnera, Jorge, Howell, Jonathan C, Sundaram, Nambirajan, Poling, Holly M, Schweitzer, Jamie I, Vallance, Jefferson E, Mayhew, Christopher N, Sun, Ying, Grabowski, Gregory, Finkbeiner, Stacy R, Spence, Jason R, Shroyer, Noah F, Wells, James M, Helmrath, Michael A
Publicado no Nat Med (2014)