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RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult
Cell cycle checkpoints induced by DNA damage play an integral role in preservation of genomic stability by allowing cells to limit the propagation of deleterious mutations. The retinoblastoma tumor suppressor (RB) is crucial for the maintenance of the DNA damage checkpoint function because it elicit...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373257/ https://ncbi.nlm.nih.gov/pubmed/14704340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg919 |
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