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RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo

The integrity of the retinoblastoma tumor suppressor (RB) pathway is critical for restraining inappropriate proliferation and suppressing tumor development in a plethora of tissues. Here adenovirus-mediated RB deletion in the liver of adult mice led to DNA replication in the absence of productive mi...

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Detalhes bibliográficos
Main Authors: Bourgo, Ryan J., Ehmer, Ursula, Sage, Julien, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069018/
https://ncbi.nlm.nih.gov/pubmed/21289097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-11-0895
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