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Regulation of RB Transcription In Vivo by RB Family Members

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase activity. While variations in RB levels may also provide an important means of controlling RB function in both normal...

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Détails bibliographiques
Auteurs principaux: Burkhart, Deborah L., Ngai, Lynn K., Roake, Caitlin M., Viatour, Patrick, Thangavel, Chellappagounder, Ho, Victoria M., Knudsen, Erik S., Sage, Julien
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838078/
https://ncbi.nlm.nih.gov/pubmed/20100864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00952-09
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