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GFP reporter mice for the retinoblastoma-related cell cycle regulator p107

The RB tumor suppressor gene is mutated in a broad range of human cancers, including pediatric retinoblastoma. Strikingly, however, Rb mutant mice develop tumors of the pituitary and thyroid glands, but not retinoblastoma. Mouse genetics experiments have demonstrated that p107, a protein related to...

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Bibliographic Details
Main Authors: Burkhart, Deborah L., Viatour, Patrick, Ho, Victoria M., Sage, Julien
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730771/
https://ncbi.nlm.nih.gov/pubmed/18719374
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