RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. In this study, we present evidence for incre...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Marshall, Aren E., Roes, Michael V., Passos, Daniel T., DeWeerd, Megan C., Chaikovsky, Andrea C., Sage, Julien, Howlett, Christopher J., Dick, Frederick A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664603/
https://ncbi.nlm.nih.gov/pubmed/31138663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00105-19
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