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RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo

The integrity of the retinoblastoma tumor suppressor (RB) pathway is critical for restraining inappropriate proliferation and suppressing tumor development in a plethora of tissues. Here adenovirus-mediated RB deletion in the liver of adult mice led to DNA replication in the absence of productive mi...

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Bibliografski detalji
Glavni autori: Bourgo, Ryan J., Ehmer, Ursula, Sage, Julien, Knudsen, Erik S.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069018/
https://ncbi.nlm.nih.gov/pubmed/21289097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-11-0895
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