Single-strand interruptions in replicating chromosomes cause double-strand breaks

Replication-dependent chromosomal breakage suggests that replication forks occasionally run into nicks in template DNA and collapse, generating double-strand ends. To model replication fork collapse in vivo, I constructed phage λ chromosomes carrying the nicking site of M13 bacteriophage and infecte...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
1. Verfasser:	Kuzminov, Andrei
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Colloquium Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131009198
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