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Single-strand interruptions in replicating chromosomes cause double-strand breaks
Replication-dependent chromosomal breakage suggests that replication forks occasionally run into nicks in template DNA and collapse, generating double-strand ends. To model replication fork collapse in vivo, I constructed phage λ chromosomes carrying the nicking site of M13 bacteriophage and infecte...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC37427/ https://ncbi.nlm.nih.gov/pubmed/11459959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131009198 |
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