Single-strand interruptions in replicating chromosomes cause double-strand breaks
Replication-dependent chromosomal breakage suggests that replication forks occasionally run into nicks in template DNA and collapse, generating double-strand ends. To model replication fork collapse in vivo, I constructed phage λ chromosomes carrying the nicking site of M13 bacteriophage and infecte...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autor: | |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2001
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131009198 |
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