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Proliferative suppression by CDK4/6 inhibition: complex function of the RB-pathway in liver tissue and hepatoma cells
BACKGROUND AND AIMS: Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide and current chemotherapeutic interventions for this disease are largely ineffective. The retinoblastoma tumor suppressor (RB) is functionally inactivated at relatively high frequency in hepatocellu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860048/ https://ncbi.nlm.nih.gov/pubmed/20100483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.01.007 |
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