RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage

BACKGROUND & AIMS: The tumor suppressors retinoblastoma (RB) and p53 are important regulators of the cell cycle. Although human cancer cells inactivate RB and p53 by many mechanisms, the cooperative roles of these proteins in tumorigenesis are complex and tissue-specific. We analyzed the coopera...

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Publicado no:Gastroenterology
Main Authors: McClendon, A. Kathleen, Dean, Jeffry L., Ertel, Adam, Fu, Zhiyan, Rivadeneira, Dayana B., Reed, Christopher A., Bourgo, Ryan J., Witkiewicz, Agnieszka, Addya, Sankar, Mayhew, Christopher N., Grimes, H. Leighton, Fortina, Paolo, Knudsen, Erik S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562673/
https://ncbi.nlm.nih.gov/pubmed/21704587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.046
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