RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage

BACKGROUND & AIMS: The tumor suppressors retinoblastoma (RB) and p53 are important regulators of the cell cycle. Although human cancer cells inactivate RB and p53 by many mechanisms, the cooperative roles of these proteins in tumorigenesis are complex and tissue-specific. We analyzed the coopera...

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Détails bibliographiques
Publié dans:Gastroenterology
Auteurs principaux: McClendon, A. Kathleen, Dean, Jeffry L., Ertel, Adam, Fu, Zhiyan, Rivadeneira, Dayana B., Reed, Christopher A., Bourgo, Ryan J., Witkiewicz, Agnieszka, Addya, Sankar, Mayhew, Christopher N., Grimes, H. Leighton, Fortina, Paolo, Knudsen, Erik S.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562673/
https://ncbi.nlm.nih.gov/pubmed/21704587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.06.046
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